PUBLICATIONS

ARTICLES

  • Motiei M, Sadan T, Zilony N, Topaz G, Popovtzer R, Topaz M. Gold nanoparticles for tracking bacteria clearance by regulated irrigation and negative pressure-assisted wound therapy. Nanomedicine, 2018, in press.
  • Dreifuss T, Ben-Gal TS, Shamalov K, Weiss A, Jacob A, Sadan T, Menachem Motiei M, and Popovtzer R. Uptake Mechanism of Metabolic-Targeted Gold Nanoparticles. Nanomedicine 2018, in press.
  • Sadan T, Cormode D, Popovtzer R. Nanoinformatics Revolutionizes Personalized Cancer Therapy; Trends in Cancer, Volume 4, Issue 6, p397–399, June 2018.
  • Barnoy EA, Popovtzer R, Fixler D. Implementing biological logic gates using gold nanoparticles conjugated to fluorophores. Proc. SPIE 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV, 105060W, 2018; doi: 10.1117/12.2287097
  • Gaikwad HK, Tsvirkun D, Ben-Nun Y, Merquiol E, Popovtzer R, Blum G, Molecular Imaging of Cancer Using X-ray Computed Tomography with Protease Targeted Iodinated Activity-Based Probes. Nano Letters 2018, DOI: 10.1021/acs.nanolett.7b03813
  • Meir R, Shamalov K, Sadan T, Motiei M, Yaari G, Cohen CJ, and Popovtzer R. Fast Image-Guided Stratification Using Anti-Programmed Death Ligand 1 Gold Nanoparticles for Cancer Immunotherapy. ACS Nano, 2017, 28;11(11):11127-11134.
  • Davidi ES, Dreifuss T, Motiei M, Shai E, Bragilovski D, Lubimov L, Kindler MJJ, Popovtzer A, Don J, Popovtzer R. Cisplatin conjugated gold nanoparticles as a theranostic agent for head and neck cancer. Head and Neck 2017, Jan;40(1):70-78.
  • Hazkani I, Motiei M, Betzer O, Sadan T, Bragilovski D, Lubimov L, Mizrachi A, Hadar T, Levi M, Ben-Aharon I, Haviv I, Popovtzer R, Popovtzer A. Can molecular profiling enhance radiotherapy? Impact of personalized targeted gold nanoparticles on radiosensitivity and imaging of adenoid cystic carcinoma. Theranostics 2017; 7(16):3962-3971. doi:10.7150/thno.19615
  • Betzer O, Perets N, Angel A, Motiei M, Sadan T, Yadid G, Offen D, and Popovtzer R. In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles. ACS Nano, 2017, 28;11(11):10883-10893.
  • Betzer O, Shilo M, Opochinsky R, Barnoy E, Motiei M, Okun E, Yadid G, Popovtzer R. The effect of nanoparticle size on the ability to cross the blood-brain barrier: an in vivo study. Nanomedicine (Lond). 2017 Jul;12(13):1533-1546.
  • Meir R, Popovtzer R. Cell tracking using gold nanoparticles and computed tomography imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017, May 24. doi: 10.1002/wnan.1480.
  • Barnoy EA, Popovtzer R, Fixler D. Development of a molecular bioswitch using fluorescence lifetime imaging: Incremental activation of fluorescein diacetate. J Biophotonics. 2017 Jul 12, doi: 10.1002/jbio.201700084.
  • Shwartz A, Betzer O, Kronfeld N, Kazimirsky G, Cazacu S, Finniss S, Lee HK, Motiei M, Dagan SY, Popovtzer R, Brodie C, Yadid G. Therapeutic Effect of Astroglia-like Mesenchymal Stem Cells Expressing Glutamate Transporter in a Genetic Rat Model of Depression.
    Theranostics. 2017 Jul 6;7(10):2690-2703.
  • J Kim, P Chhour, J Hsu, HI Litt, VA Ferrari, R Popovtzer, DP Cormode. Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography. Bioconjugate Chemistry, 2017 Jun 21;28(6):1581-1597.
  • Meir R, Betzer O, Motiei M, Kronfeld N, Brodie C, Popovtzer R, Design principles for noninvasive, longitudinal and quantitative cell tracking with nanoparticle-based CT imaging. Nanomedicine: Nanotechnology, Biology, and Medicine, 13, 421 – 429, 2017
  • Vegerhof A, Barnoy EA, Motiei M, Malka D, Danan Y, Zalevsky Z and Popovtzer R, "Targeted Magnetic Nanoparticles for Mechanical Lysis of Tumor Cells by Low-Amplitude Alternating Magnetic Field". Materials, 9 (11), 943, 2016.
  • Vegerhof A, Motei M, Rudinzky A, Malka D, Popovtzer R, Zalevsky Z, "Thermal Therapy with Magnetic Nanoparticles for Cell Destruction". Biomed Opt Express, Oct 17;7(11):4581-4594, 2016
  • Menachem Motiei, Tamar Dreifuss, Oshra Betzer, Hana Panet, Aron Popovtzer, Jordan Santana, Galith Abourbeh, Eyal Mishani, and Rachela Popovtzer; “Differentiating Between Cancer and Inflammation: A Metabolic-Based Method for Functional Computed Tomography Imaging” ACS nano. 10 (3), pp 3469–3477, 2016.
  • Aron Popovtzer, Aviram Mizrahi, Menachem Motiei, Dimitri Bragilovski, Leon Lubimov, Mattan Levy, Ohad Hilly, Irit Ben Aharon, and Rachela Popovtzer; " Actively targeted gold nanoparticles as novel radiosensitizer agents: in vivo head and neck cancer model". Nanoscale 8, 2678 - 2685, 2016.
  • Adi Vegerhof , Arkady Rudinzky, Yevgeny Beiderman, Hamootal Duadi, Rachela Popovtzer and Zeev Zalevsky; “Manipulated magnetic nano particles for Photonic biomedical mapping”. Nanoscience and Nanotechnology Letters, October 2015.
  • Malka Shilo, Peter Berenstein, Tamar Dreifuss, Yuval Nash, Guy Goldsmith, Gila Kazimirsky, Menachem Motiei, Dan Frenkel, Chaya Brodie and Rachela Popovtzer; “Insulin-Coated Gold Nanoparticles as a New Concept for Personalized and Adjustable Glucose Regulation”. Nanoscale, 7, 20489 - 20496, 2015.
  • O. Betzer, R. Meir, T. Dreifuss, K. Shamalov, M. Motiei, A. Shwartz, K. Baranes, C. J. Cohen, N. Shraga-Heled, R. Ofir, G. Yadid & R. Popovtzer; “In-vitro Optimization of Nanoparticle-Cell Labeling Protocols”. Scientific Reports, 5, Article no. 15400, 2015.
  • Eran A. Barnoy, Dror Fixler, Rachela Popovtzer, Tsviya Nayhoz and Krishanu Ray; “An ultra-sensitive dual imaging system of diffusion reflection and fluorescence lifetime imaging microscopy using metal enhanced fluorescence in solid phantoms”. Nano Research, 8 (12), 3912-3921, 2015.
  • Shmulik Schwartz, Dror Fixler, Rachela Popovtzer, and Orit Shefi: “Fluorescence life-time imaging and steady state polarization for examining binding of fluorophores to gold nanoparticles”. Journal of Biophotonics, 8, No. 11–12, 944–951, 2015.
  • Malka Shilo , Anat Sharon , Koby Baranes , Menachem Motiei , Jean-Paul M Lellouche and Rachela Popovtzer; " The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model". Journal of Nanobiotechnology, 13:19, 2015.
  • Oshra Betzer, Rinat Ankri, Menachem Motiei and Rachela Popovtzer; “Theranostic approach for cancer treatment: multifunctional Gold nanorods for optical imaging and photothermal therapy” Journal of Nanomaterials, 2015
  • Tamar Dreifuss, Oshra Betzer, Malka Shilo, Aron Popovtzer, Menachem Motiei and Rachela Popovtzer; A Challenge for Theranostics: Is the Optimal Particle for Therapy Also Optimal for Diagnostics?; Nanoscale 7, 15175-15184, 2015.
  • Rinat Meir, Kata Shamalov, Oshra Betzer, Menachem Motiei, Ronen Yehuda, Aron Popovtzer, Rachela Popovtzer and Cyrille J. Cohen, "Nanomedicine for Cancer Immunotherapy: Tracking Cancer-Specific T-cells in vivo with Gold Nanoparticles and CT Imaging", ACS nano, 9 (6), 6363-6372, 2015.
  • Rinat Meir, Menachem Motiei & Rachela Popovtzer; "Gold nanoparticles for in vivo cell tracking" Nanomedicine, DOI 10.2217/nnm.14.129, 2014.
  • O. Betzer, A. Shwartz, M. Motiei, G. Kazimirsky, I. Gispan, E. Damti, C. Brodie, G. Yadid and R. Popovtzer; "Nanoparticle-Based CT Imaging Technique for Longitudinal and Quantitative Stem Cell Tracking within the Brain: Application in Neuropsychiatric Disorders" ACS Nano DOI: 10.1021/nn503131h, 8 (9), 9274-9285, 2014.
  • Rachela Popovtzer; “Biomedical applications of gold nanomaterials; Nanomedicine 9, (13), 1903-1904, 2014.
  • R. Ankri, D. Leshem-Lev, D. Fixler, R. Popovtzer, M. Motiei, R. Kornowski, E. Hochhauser, E. I Lev “Gold Nanorods as Absorption Contrast Agents for the Noninvasive Detection of Arterial Vascular Disorders Based on Diffusion Reflection Measurements”. NanoLetters, 14, 5, 2681-2687, 2014.
  • Malka Shilo, Menachem Motiei, Panet Hana and Rachela Popovtzer; Transport of Nanoparticles through the Blood-Brain Barrier for Imaging and Therapeutic Applications; Nanoscale, 6 (4), 2146 – 2152, 2014.
  • Rinat Ankri, Dolev Peretz, Menachem Motiei, Osnat Sella-Tavor and Rachela Popovtzer; New optical method for enhanced detection of colon cancer by capsule endoscopy; Nanoscale; 5, 9806-9811, 2013.
  • Taeyjuana Y. Curry, Raoul Kopelman, Malka Shilo and Rachela Popovtzer; Multifunctional Theranostic Gold Nanoparticles for Targeted CT Imaging and Photothermal Therapy; Contrast Media and Molecular Imaging, 9 (1) 53-61, 2013.
  • H. Duadi, D. Fixler and R. Popovtzer; Dependence of Light Scattering profile in Tissue on Blood Vessel Diameter and Distribution - a Computer Simulation Study. Journal of Biomedical Optics, (18) 11, Article Number: 111408 Published: Nov 2013.
  • Rinat Ankri, Amihai Meiri, Shemuel I. Lau, Menachem Motiei, Rachela Popovtzer, Dror Fixler; Intercoupling surface plasmon resonance and diffusion reflection measurements for real-time cancer detection. Journal of Biophotonics, 6 (2), 188-196 2013.
  • Kobi Jakobsohn, Menachem Mutiei, Moshe Sinvani and Rachela Popovtzer; Towards Real Time Detection of Tumor Margins Using Photothermal Imaging of Immune-targeted Gold Nanoparticles. International Journal of Nanomedicine, 4707 - 4713 2012.
  • Vital Peretz, Menachem Motiei, Chaim Sukenik, and Rachela Popovtzer, The effect of nanoparticle size on cellular binding probability. Journal of Atomic Molecular and Optical Physics, vol 2012, 1-7, 2012.
  • Rinat Ankri, Vital Peretz, Menachem Motiei, Rachela Popovtzer and Dror Fixler; A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods: International Journal of Nanomedicine; 449-455, 2012.
  • Malka Shilo, Tobi Reuveni, Menachem Motiei and Rachela Popovtzer, Nanoparticles as computed tomography contrast agents: current status and future perspectives; review paper (invited). Nanomedicine. 257-269, 2012.
  • Reuveni T, Motiei. M., Romman Z, Popovtzer A, Popovtzer R. Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study. International Journal of Nanomedicine; 1-6, 2011.
  • Y. Shacham-Diamand, S. Belkin , J. Rishpon, T. Elad, S. Melamed, A. Biran, S. Yagur-Kroll, R. Almog, R. Daniel, H. Ben-Yoav , A. Rabner , S. Vernick , N. Elman and R. Popovtzer; “Optical and Electrical Interfacing Technologies for Living Cell Bio-Chips”, Current Pharmaceutical Biotechnology, 376-383, 2010.
  • Rachela Popovtzer, Ashish Agrawal, Nicholas A. Kotov, Aron Popovtzer, James Balter, Thomas. E. Carey and Raoul Kopelman. “Targeted Gold Nanoparticles enable Molecular CT Imaging of Cancer”. NanoLetters, 8 (12) Pages: 4593-4596, 2008.
  • R. Popovtzer, T. Neufeld, A. Popovtzer, I. Rivkin, R. Margalit, D. Engel, A. Nudelman, A. Rephaeli, J. Rishpon and Y.Shacham-Diamand "Electrochemical lab on a chip for high-throughput analysis of anticancer drugs efficiency"; Nanomedicine-Nanotechnology Biology and Medicine; 4 (2): 121-126, 2008.
  • Rachela Popovtzer, Ashish Agrawal, Nicholas A. Kotov, Aron Popovtzer, James Balter, Thomas. E. Carey and Raoul Kopelman "Gold Nano-Probes as Targeted CT Contrast Agents for In-vivo cancer Imaging" NSTI Nanotech , VOL 2, Technical Proceeding: 5-7, 2008.
  • Rachela Popovtzer, Tova Neufeld, Ilia Rivkin, Rimona margalit, Dikla Engel, Abraham Nudelman, Ada Rephaeli, Judith Rishpon and Yosi Shacham-Diamand. “High-Throughput Detection of Colon Cancer Cells Response to Different Drug Treatments”. Nanomedicine 4 (2): 121-126 June 2008.
  • Rachela Popovtzer, Amir Natan and Yosi Shacham-Diamand. “Mathematical model of whole cell based bio-chip: An electrochemical biosensor for water toxicity detection”. Journal of electro-analytical chemistry 602 (1): 17-23 APR 1, 2007.
  • Tova Neufeld, Dvora Biran, Rachela Popovtzer, Tamir Erez, Eliora Z. Ron and Judith Rishpon. "Genetically Engineered pfabA pfabR Bacteria: an Electrochemical Whole Cell Biosensor for Detection of Water Toxicity". Analytical Chemistry, 78 (14): 4952-4956 Jul 2006.
  • Rachela Popovtzer, Tova Neufeld, Eliora Z. Ron, Judith Rishpon, and Yosi Shacham-Diamand. " Electrochemical ‘Lab-on-a-Chip’ for Toxicity Detection in Water" NSTI Nanotech , VOL 2, Technical Proceeding: 205-208, 2006.
  • Rachela Popovtzer, Tova Neufeld, Eliora Z. Ron, Judith Rishpon, and Yosi Shacham-Diamand. "Novel Integrated Electrochemical Nano-Bio-Chip for Toxicity Detection in Water". Nano Letters 5 (6): 1023-1027, June 2005.

PATENTS

  • Glucose Conjugated Gold Nanoparticle, Rachela Popovtzer, US20170189560 A1
  • Immuno-targeted plasmonic nanoparticles for spectroscopic detection of colon cancer. R. Popovtzer, D. Fixler, M. Motiei, R. Ankri and D. Peretz. U.S. Patent # 61/820,190, issued: May-2013.
  • Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the disease. J. Rishpon, R. Popovtzer, Y. Shacham-Diamand, T. Neufeld and S. Vernick. U.S. Patent 20120288877. Issued: Nov. 2012.
  • Hemodialysis System; Rachela Popovtzer and Yossi Machtai. U.S. Patent # 2012/050317, issued: Aug. 2012.
  • Real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles; Kobi Jakobsohn, Menachem Mutiei, Moshe Sinvani, Zeev Zalevsky and Rachela Popovtzer. U.S. Patent # 61/659,444, issued: June 2012.

BOOKS

  • Rachela Popovtzer, Tova Neufeld, Eliora Z. Ron, Judith Rishpon, and Yosi Shacham-Diamand. "Electrochemical Detection of Biological Reactions using a Novel Nano-Bio-Chip Array", Sensors & Actuators B: Chemical, 119 (2): 664-672 Feb, 2006

BOOK CHAPTERS

  • Tamar Dreifuss, Eran Barnoy, Menachem Motiei, Rachela Popovtzer; “Theranostic Gold Nanoparticles for CT Imaging”, Design and Applications of Nanoparticles in Biomedical Imaging, Springer, 2016
  • Malka Shilo, Menachem Motiei and Rachela Popovtzer; "Nanoparticles in Computed Tomography". Nanotechnology in Modern Medical Imaging and Interventions, Nova Publishers, 2013
  • Y. Shacham-Diamand, R. Almog, R. Daniel, A. Rabner and R Popovtzer, "Nano-Bio Interfacing with Living Cells Biochips" Handbook of Nanophysics: Nanomedicine and Nanorobotics" CRC Press, 2010.
  • R. Popovtzer, Y. Shacham-Diamand and J. Rishpon, "An electrochemical biochip for the detection of pollutants" Edited by Martin Rothlisberger "Handbook Of Biosensors And Biochips" John Wiley & Sons, UK, 2006.
  • R. Popovtzer, J. Rishpon and Y. Shacham-Diamand, "Nano-bio electrochemical interfacing – linking cell biology and micro-electronics" Edited by T. Osaka, M. Datta and Y. Shaham-Diamond, "New Frontiers in Electrochemical Sciences and Technology" Springer, 2006.

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