PUBLICATIONS

ARTICLES

  • Meir R, Shamalov K, Sadan T, Motiei M, Yaari G, Cohen CJ, and Popovtzer R. Fast Image-Guided Stratification Using Anti-Programmed Death Ligand 1 Gold Nanoparticles for Cancer Immunotherapy. ACS Nano, Oct 2017 (Epub before print). DOI: 10.1021/acsnano.7b05299
  • Davidi ES, Dreifuss T, Motiei M, Shai E, Bragilovski D, Lubimov L, Kindler MJJ, Popovtzer A, Don J, Popovtzer R. Cisplatin conjugated gold nanoparticles as a theranostic agent for head and neck cancer. Head and Neck 2017, in press.
  • Hazkani I, Motiei M, Betzer O, Sadan T, Bragilovski D, Lubimov L, Mizrachi A, Hadar T, Levi M, Ben-Aharon I, Haviv I, Popovtzer R, Popovtzer A. Can molecular profiling enhance radiotherapy? Impact of personalized targeted gold nanoparticles on radiosensitivity and imaging of adenoid cystic carcinoma. Theranostics 2017; 7(16):3962-3971. doi:10.7150/thno.19615
  • Betzer O, Perets N, Angel A, Motiei M, Sadan T, Yadid G, Offen D, and Popovtzer R. In Vivo Neuroimaging of Exosomes Using Gold Nanoparticles. ACS Nano, Sept. 2017 (Epub before print). DOI: 10.1021/acsnano.7b04495
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  • Betzer O, Shilo M, Opochinsky R, Barnoy E, Motiei M, Okun E, Yadid G, Popovtzer R. The effect of nanoparticle size on the ability to cross the blood-brain barrier: an in vivo study. Nanomedicine (Lond). 2017 Jul;12(13):1533-1546.
  • Meir R, Popovtzer R. Cell tracking using gold nanoparticles and computed tomography imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017, May 24. doi: 10.1002/wnan.1480. [Epub ahead of print]
  • Barnoy EA, Popovtzer R, Fixler D. Development of a molecular bioswitch using fluorescence lifetime imaging: Incremental activation of fluorescein diacetate. J Biophotonics. 2017 Jul 12, doi: 10.1002/jbio.201700084. [Epub ahead of print]
  • Shwartz A, Betzer O, Kronfeld N, Kazimirsky G, Cazacu S, Finniss S, Lee HK, Motiei M, Dagan SY, Popovtzer R, Brodie C, Yadid G. Therapeutic Effect of Astroglia-like Mesenchymal Stem Cells Expressing Glutamate Transporter in a Genetic Rat Model of Depression.
    Theranostics. 2017 Jul 6;7(10):2690-2703.
  • J Kim, P Chhour, J Hsu, HI Litt, VA Ferrari, R Popovtzer, DP Cormode. Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography. Bioconjugate Chemistry, 2017 Jun 21;28(6):1581-1597.
  • Meir R, Betzer O, Motiei M, Kronfeld N, Brodie C, Popovtzer R, Design principles for noninvasive, longitudinal and quantitative cell tracking with nanoparticle-based CT imaging. Nanomedicine: Nanotechnology, Biology, and Medicine, 13, 421 – 429, 2017
  • Vegerhof A, Barnoy EA, Motiei M, Malka D, Danan Y, Zalevsky Z and Popovtzer R, "Targeted Magnetic Nanoparticles for Mechanical Lysis of Tumor Cells by Low-Amplitude Alternating Magnetic Field". Materials, 9 (11), 943, 2016.
  • Vegerhof A, Motei M, Rudinzky A, Malka D, Popovtzer R, Zalevsky Z, "Thermal Therapy with Magnetic Nanoparticles for Cell Destruction". Biomed Opt Express, Oct 17;7(11):4581-4594, 2016
  • Menachem Motiei, Tamar Dreifuss, Oshra Betzer, Hana Panet, Aron Popovtzer, Jordan Santana, Galith Abourbeh, Eyal Mishani, and Rachela Popovtzer; “Differentiating Between Cancer and Inflammation: A Metabolic-Based Method for Functional Computed Tomography Imaging” ACS nano. 10 (3), pp 3469–3477, 2016.
  • Aron Popovtzer, Aviram Mizrahi, Menachem Motiei, Dimitri Bragilovski, Leon Lubimov, Mattan Levy, Ohad Hilly, Irit Ben Aharon, and Rachela Popovtzer; " Actively targeted gold nanoparticles as novel radiosensitizer agents: in vivo head and neck cancer model". Nanoscale 8, 2678 - 2685, 2016.
  • Adi Vegerhof , Arkady Rudinzky, Yevgeny Beiderman, Hamootal Duadi, Rachela Popovtzer and Zeev Zalevsky; “Manipulated magnetic nano particles for Photonic biomedical mapping”. Nanoscience and Nanotechnology Letters, October 2015.
  • Malka Shilo, Peter Berenstein, Tamar Dreifuss, Yuval Nash, Guy Goldsmith, Gila Kazimirsky, Menachem Motiei, Dan Frenkel, Chaya Brodie and Rachela Popovtzer; “Insulin-Coated Gold Nanoparticles as a New Concept for Personalized and Adjustable Glucose Regulation”. Nanoscale, 7, 20489 - 20496, 2015.
  • O. Betzer, R. Meir, T. Dreifuss, K. Shamalov, M. Motiei, A. Shwartz, K. Baranes, C. J. Cohen, N. Shraga-Heled, R. Ofir, G. Yadid & R. Popovtzer; “In-vitro Optimization of Nanoparticle-Cell Labeling Protocols”. Scientific Reports, October 2015.
  • Eran A. Barnoy, Dror Fixler, Rachela Popovtzer, Tsviya Nayhoz and Krishanu Ray; “An ultra-sensitive dual imaging system of diffusion reflection and fluorescence lifetime imaging microscopy using metal enhanced fluorescence in solid phantoms”. Nano Research, 8 (12), 3912-3921, 2015.
  • Shmulik Schwartz, Dror Fixler, Rachela Popovtzer, and Orit Shefi: “Fluorescence life-time imaging and steady state polarization for examining binding of fluorophores to gold nanoparticles”. Journal of Biophotonics, 8, No. 11–12, 944–951, 2015.
  • Malka Shilo , Anat Sharon , Koby Baranes , Menachem Motiei , Jean-Paul M Lellouche and Rachela Popovtzer; " The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model". Journal of Nanobiotechnology, 13:19, 2015.
  • Oshra Betzer, Rinat Ankri, Menachem Motiei and Rachela Popovtzer; “Theranostic approach for cancer treatment: multifunctional Gold nanorods for optical imaging and photothermal therapy” Journal of Nanomaterials, 2015
  • Tamar Dreifuss, Oshra Betzer, Malka Shilo, Aron Popovtzer, Menachem Motiei and Rachela Popovtzer; A Challenge for Theranostics: Is the Optimal Particle for Therapy Also Optimal for Diagnostics?; Nanoscale, DOI: 10.1039/C5NR03119B, 2015.
  • Rinat Meir, Kata Shamalov, Oshra Betzer, Menachem Motiei, Ronen Yehuda, Aron Popovtzer, Rachela Popovtzer and Cyrille J. Cohen, "Nanomedicine for Cancer Immunotherapy: Tracking Cancer-Specific T-cells in vivo with Gold Nanoparticles and CT Imaging", ACS nano, 9 (6), 6363-6372, 2015.
  • Rinat Meir, Menachem Motiei & Rachela Popovtzer; "Gold nanoparticles for in vivo cell tracking" Nanomedicine, DOI 10.2217/nnm.14.129, 2014.
  • O. Betzer, A. Shwartz, M. Motiei, G. Kazimirsky, I. Gispan, E. Damti, C. Brodie, G. Yadid and R. Popovtzer; "Nanoparticle-Based CT Imaging Technique for Longitudinal and Quantitative Stem Cell Tracking within the Brain: Application in Neuropsychiatric Disorders" ACS Nano DOI: 10.1021/nn503131h, 8 (9), 9274-9285, 2014.
  • Rachela Popovtzer; “Biomedical applications of gold nanomaterials; Nanomedicine 9, (13), 1903-1904, 2014.
  • R. Ankri, D. Leshem-Lev, D. Fixler, R. Popovtzer, M. Motiei, R. Kornowski, E. Hochhauser, E. I Lev “Gold Nanorods as Absorption Contrast Agents for the Noninvasive Detection of Arterial Vascular Disorders Based on Diffusion Reflection Measurements”. NanoLetters, DOI: 10.1021/nl500573d, 2014.
  • Malka Shilo, Menachem Motiei, Panet Hana and Rachela Popovtzer; Transport of Nanoparticles through the Blood-Brain Barrier for Imaging and Therapeutic Applications; Nanoscale, 6 (4), 2146 – 2152, 2014.
  • Rinat Ankri, Dolev Peretz, Menachem Motiei, Osnat Sella-Tavor and Rachela Popovtzer; New optical method for enhanced detection of colon cancer by capsule endoscopy; Nanoscale; 5, 9806-9811, 2013.
  • Taeyjuana Y. Curry, Raoul Kopelman, Malka Shilo and Rachela Popovtzer; Multifunctional Theranostic Gold Nanoparticles for Targeted CT Imaging and Photothermal Therapy; Contrast Media and Molecular Imaging, 9 (1) 53-61, 2013.
  • H. Duadi, D. Fixler and R. Popovtzer; Dependence of Light Scattering profile in Tissue on Blood Vessel Diameter and Distribution - a Computer Simulation Study. Journal of Biomedical Optics, (18) 11, Article Number: 111408 Published: Nov 2013.
  • Rinat Ankri, Amihai Meiri, Shemuel I. Lau, Menachem Motiei, Rachela Popovtzer, Dror Fixler; Intercoupling surface plasmon resonance and diffusion reflection measurements for real-time cancer detection. Journal of Biophotonics, 6 (2), 188-196 2013.
  • Kobi Jakobsohn, Menachem Mutiei, Moshe Sinvani and Rachela Popovtzer; Towards Real Time Detection of Tumor Margins Using Photothermal Imaging of Immune-targeted Gold Nanoparticles. International Journal of Nanomedicine, 4707 - 4713 2012.
  • Vital Peretz, Menachem Motiei, Chaim Sukenik, and Rachela Popovtzer, The effect of nanoparticle size on cellular binding probability. Journal of Atomic Molecular and Optical Physics, vol 2012, 1-7, 2012.
  • Rinat Ankri, Vital Peretz, Menachem Motiei, Rachela Popovtzer and Dror Fixler; A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods: International Journal of Nanomedicine; 449-455, 2012.
  • Malka Shilo, Tobi Reuveni, Menachem Motiei and Rachela Popovtzer, Nanoparticles as computed tomography contrast agents: current status and future perspectives; review paper (invited). Nanomedicine. 257-269, 2012.
  • Reuveni T, Motiei. M., Romman Z, Popovtzer A, Popovtzer R. Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study. International Journal of Nanomedicine; 1-6, 2011.
  • Y. Shacham-Diamand, S. Belkin , J. Rishpon, T. Elad, S. Melamed, A. Biran, S. Yagur-Kroll, R. Almog, R. Daniel, H. Ben-Yoav , A. Rabner , S. Vernick , N. Elman and R. Popovtzer; “Optical and Electrical Interfacing Technologies for Living Cell Bio-Chips”, Current Pharmaceutical Biotechnology, 376-383, 2010.
  • Rachela Popovtzer, Ashish Agrawal, Nicholas A. Kotov, Aron Popovtzer, James Balter, Thomas. E. Carey and Raoul Kopelman. “Targeted Gold Nanoparticles enable Molecular CT Imaging of Cancer”. NanoLetters, 8 (12) Pages: 4593-4596, 2008.
  • R. Popovtzer, T. Neufeld, A. Popovtzer, I. Rivkin, R. Margalit, D. Engel, A. Nudelman, A. Rephaeli, J. Rishpon and Y.Shacham-Diamand "Electrochemical lab on a chip for high-throughput analysis of anticancer drugs efficiency"; Nanomedicine-Nanotechnology Biology and Medicine; 4 (2): 121-126, 2008.
  • Rachela Popovtzer, Ashish Agrawal, Nicholas A. Kotov, Aron Popovtzer, James Balter, Thomas. E. Carey and Raoul Kopelman "Gold Nano-Probes as Targeted CT Contrast Agents for In-vivo cancer Imaging" NSTI Nanotech , VOL 2, Technical Proceeding: 5-7, 2008.
  • Rachela Popovtzer, Tova Neufeld, Ilia Rivkin, Rimona margalit, Dikla Engel, Abraham Nudelman, Ada Rephaeli, Judith Rishpon and Yosi Shacham-Diamand. “High-Throughput Detection of Colon Cancer Cells Response to Different Drug Treatments”. Nanomedicine 4 (2): 121-126 June 2008.
  • Rachela Popovtzer, Amir Natan and Yosi Shacham-Diamand. “Mathematical model of whole cell based bio-chip: An electrochemical biosensor for water toxicity detection”. Journal of electro-analytical chemistry 602 (1): 17-23 APR 1, 2007.
  • Rachela Popovtzer, Tova Neufeld, Eliora Z. Ron, Judith Rishpon, and Yosi Shacham-Diamand. "Electrochemical Detection of Biological Reactions using a Novel Nano-Bio-Chip Array", Sensors & Actuators B: Chemical, 119 (2): 664-672 Feb, 2006
  • Tova Neufeld, Dvora Biran, Rachela Popovtzer, Tamir Erez, Eliora Z. Ron and Judith Rishpon. "Genetically Engineered pfabA pfabR Bacteria: an Electrochemical Whole Cell Biosensor for Detection of Water Toxicity". Analytical Chemistry, 78 (14): 4952-4956 Jul 2006.
  • Rachela Popovtzer, Tova Neufeld, Eliora Z. Ron, Judith Rishpon, and Yosi Shacham-Diamand. " Electrochemical ‘Lab-on-a-Chip’ for Toxicity Detection in Water" NSTI Nanotech , VOL 2, Technical Proceeding: 205-208, 2006.
  • Rachela Popovtzer, Tova Neufeld, Eliora Z. Ron, Judith Rishpon, and Yosi Shacham-Diamand. "Novel Integrated Electrochemical Nano-Bio-Chip for Toxicity Detection in Water". NanoLetters 5 (6): 1023-1027, June 2005.

PATENTS

  • Glucose Conjugated Gold Nanoparticle, Rachela Popovtzer, US20170189560 A1
  • Immuno-targeted plasmonic nanoparticles for spectroscopic detection of colon cancer. R. Popovtzer, D. Fixler, M. Motiei, R. Ankri and D. Peretz. U.S. Patent # 61/820,190, issued: May-2013.
  • Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the disease. J. Rishpon, R. Popovtzer, Y. Shacham-Diamand, T. Neufeld and S. Vernick. U.S. Patent 20120288877. Issued: Nov. 2012.
  • Hemodialysis System; Rachela Popovtzer and Yossi Machtai. U.S. Patent # 2012/050317, issued: Aug. 2012.
  • Real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles; Kobi Jakobsohn, Menachem Mutiei, Moshe Sinvani, Zeev Zalevsky and Rachela Popovtzer. U.S. Patent # 61/659,444, issued: June 2012.

BOOK CHAPTERS

  • Malka Shilo, Menachem Motiei and Rachela Popovtzer; "Nanoparticles in Computed Tomography". Nanotechnology in Modern Medical Imaging and Interventions, Nova Publishers, 2013
  • Y. Shacham-Diamand, R. Almog, R. Daniel, A. Rabner and R Popovtzer, "Nano-Bio Interfacing with Living Cells Biochips" Handbook of Nanophysics: Nanomedicine and Nanorobotics" CRC Press, 2010.
  • R. Popovtzer, Y. Shacham-Diamand and J. Rishpon, "An electrochemical biochip for the detection of pollutants" Edited by Martin Rothlisberger "Handbook Of Biosensors And Biochips" John Wiley & Sons, UK, 2006.
  • R. Popovtzer, J. Rishpon and Y. Shacham-Diamand, "Nano-bio electrochemical interfacing – linking cell biology and micro-electronics" Edited by T. Osaka, M. Datta and Y. Shaham-Diamond, "New Frontiers in Electrochemical Sciences and Technology" Springer, 2006.

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