Prof. Rachela Popovtzer is the Vice Dean of the Faculty of Engineering at Bar Ilan University, and a member of the Bar-Ilan Institute of Nanotechnology and Advanced Materials (BINA). She has previously served as head of the Bioengineering Track at Bar Ilan University, and was a visiting Professor at Memorial Sloan Kettering Cancer Center, NY.
Prof. Popovtzer is a winner of numerous international biomedical grants and awards, from the NIH, ISF and the Ministry of Science and Technology.
She has recently been awarded 8 million Euro from the European Union's Horizon 2020 program, to scientifically lead a European consortium focused on developing multimodal nanoparticles for non-invasive tracking of therapeutic stem cells for muscle regeneration.
*Golden Exosomes Selectively Target Pathological Brain Regions*
Exosomes enable intercellular communication at local or distant sites. Although they have been found to cross the blood brain barrier, their migration and homing abilities within the brain remain unstudied. We have recently developed a method for longitudinal and quantitative in vivo neuroimaging of exosomes based on the superior visualization abilities of classical X-ray computed tomography (CT), combined with gold nanoparticles as labeling agents. We used this technique to track the migration and homing patterns of intranasally administrated exosomes derived from bone marrow mesenchymal stem cells in different brain pathologies, including stroke, autism, Parkinson’s disease, and Alzheimer’s disease. We found that these exosomes specifically targeted and accumulated in pathologically relevant murine models brains regions. The exosome homing mechanism is inflammatory-driven, and the exosomes are selectively uptaken by neuronal cells in the pathological regions.
These findings have important implications for using exosomes as targeted drug carriers in various brain pathologies.
For further details, please see:
Perets et al., Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders. Nano Letters 2019
Prof. Popovtzer gave a talk on nanoparticles in medicine, at the Biennial Conference on Science & Diplomacy, under the auspices of M.K. Ofir Akunis (center), the Minister of Science and Technology. Dr. Andrei Broisman (left), Director of Applied Science and Engineering at the Ministry of Science was also part of this conference.More news
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