Prof. Rachela Popovtzer is Head of the Laboratory of Nanomedicine in the Faculty of Engineering at Bar Ilan University. She is also a member of the Bar-Ilan Institute of Nanotechnology and Advanced Materials (BINA) and Vice Dean of the Faculty of Engineering. She has served as Head of the Bioengineering Track at Bar Ilan University, and a Visiting Professor at Memorial Sloan Kettering Cancer Center. Prof. Popovtzer received her M.Sc. and PhD in Electrical Engineering from Tel Aviv University, and her B.Sc. in Physics from BIU. She was a postdoctoral fellow at the Prof. Raoul Kopelman lab, University of Michigan. Prof. Popovtzer is a winner of numerous international grants and awards, such as the Intel Prize, Crown Foundation Award, EU Environment and Living foundation Prize, and the Atol Charitable Trust Fellow in Nanomedicine. Her current research interest focuses on the development of ’smart’ nanoprobes for theranostic applications.
Cell-based therapies show contradictory results in clinical trials, preventing their further advancement and application in humans. Vigorous elucidation of mechanisms underlying the long-term fate of transplanted cells is therefore critical.
To answer this need, we developed a technique for noninvasive cell tracking, applying gold nanoparticles and CT imaging. We then defined design principles for long-term and quantitative imaging of the therapeutic cells, in a mouse model of Duchenne muscular dystrophy. We show that the cells can be tracked over long periods of time using CT, detecting as few as 500 cells and successfully monitoring their functionality. We also used image analysis tools to accurately quantify the number of cells in the muscle.
This cell tracking technology has the potential to advance the future of cell therapy, and become an essential tool in pre-clinical, as well as clinical trials.
Meir R, Betzer O, Motiei M, Kronfeld N, Brodie C, Popovtzer R. Design principles for noninvasive, longitudinal and quantitative cell tracking with nanoparticle-based CT imaging. Nanomedicine: Nanotechnology, Biology, and Medicine, 13, 421 – 429, 2017.
Our lab welcomes our research partner, Prof. Zhuang Liu, of Soochow University, China! Prof. Liu gave a fascinating talk at the Nano-IL conference, followed by a tour of Jerusalem.More news
Congratulations to our PhD student Chen Tzror-Azenkot for receiving a pretigious scholarship from the Ministry of Science and Technology!
Chen recently presented her research on liposomes for cancer diagnosis, at the Israeli Chapter of the Controlled Release Society conference.
*Pictured: Chen discussing her research with Hezi Bernholtz, co-inventor of the liposomal cancer drug Doxil.
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